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lithium arsenate is a white crystalline compound composed of lithium and arsenic, and is used for scientific research and in the production of electronic devices such as semiconductors. It is also widely used as a reagent and in chemical reactions. lithium arsenate is easily synthesized by reacting lithium hydroxide with arsenic acid.
Arsenic is naturally occurring in the earth’s crust, and it can be released during mining operations and spread through the soil. Once absorbed into the environment, arsenic can be carried by rainfall and rivers to groundwater, which may have high concentrations of this toxic element.
Exposure to arsenic may cause several diseases in humans such as gastrointestinal tract problems, skin problems and even cancer. The mode of action of arsenic intoxication may involve alterations in the cellular signaling pathways or inhibition of the cell cycle. This may result in cellular dysfunction such as cell proliferation, apoptosis and oxidative stress.
Besides the cellular abnormalities, arsenic exposure may affect the reproductive system, causing toxicity in the testis and spermatogenesis. It may also lead to cardiovascular disease and neurological effects such as confusion, numbness and hallucinations.
The toxic effects of arsenic can be mitigated by dietary supplements, and lithium is one of them. A study found that lithium treatment significantly enhances the anti-oxidative effects of red blood cells on arsenic-treated rats. This effect is attributed to the inhibition of apoptosis through the overexpression of Bcl-2 and disruption of a specific DNA repair pathway (Ding et al., 2009).