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jones reagent density
The oxidation of alcohols to ketones (H2CrO3) and carboxylic acids is one of the most common organic chemistry applications for chromic acid. This reagent is prepared by mixing a mixture of chromic anhydride and dilute sulfuric acid in acetone.
It is also useful for a variety of other redox reactions. The Jones reagent is commonly used to oxidize secondary alcohols to ketones in an acetone solution, but it can be a convenient and safe method for oxidizing primary alcohols as well.
Jones Reagent Descriptive Information
Generally speaking, chromic acid is an excellent oxidizing agent for a range of organic compounds including alcohols and polymers. In fact, it is the oxidizer of choice for many organic reactions because it is inexpensive and is nontoxic.
When compared to other common oxidizing agents such as hydrogen peroxide, chromic acid is much more stable in acidic conditions and does not lose stability even at room temperature. In addition, chromic acid can be dissolved in aqueous sulfuric acid without the need for heating.
Another benefit of chromic acid is its ability to oxidize aldehydes that would otherwise be difficult to do. This is especially the case for benzyl and allyl alcohols. It is also the reagent of choice for oxidizing a wide array of carbon-carbon multiple bonds and some unsaturated groups to aldehydes. It has also been used to epoxide and cyclize enols and aldehydes, and to synthesize 3b,11b-dihydroxy-9a-halo-5a-androstane-17-ones 4a-c and the tridecacyclic pyrazines 254 and 255 (Scheme 2.39). A variety of other chemical properties, such as reaction time, rate determining step and selectivity, are also important considerations in deciding on a chromic acid as the oxidizer for a particular organic synthesis.